Anti-estrogens are medicines that inhibit the production, secretion, transport of estrogens in the organism. Small doses of anti-estrogens stimulate the production and release of gonadotropic hormones (prolactin, follicle-stimulating and luteinizing hormone) and thus stimulate ovulation. In high concentrations they suppress gonadotropins secretion. Anti-estrogens work by interacting with estrogen-dependent receptors and thus prevent aromatization of steroid hormones and their conversion into estrogens. Among anti-estrogens Proviron and Clomid are the most widely used in medical practice.
Proviron is used for the treatment of male sexual disorders. After administration, Proviron interacts not only with aromatase but also with androgen receptors. It is actively used by athletes for its ability to enhance muscle stiffness, increase vascularity, making rippling muscles. The dose for Proviron is indicated individually depending on the dose of other steroids. Usually 25mg of proviron is enough to avoid aromatization of 250mg of testosterone weekly. As usual the medication is used for 2 -4 weeks.
Another anti-estrogen medication is Clomid. Clomid contains the active ingredient clomiphene citrate. The molecule of clomiphene is very close to tamoxifen. Clomid is primary used to stimulate ovulation in women with infertility. Being a synthetic estrogen, clomiphene works by blocking the receptors of estrogens. Clomiphene is less effective as anti-estrogen as tamoxifen. The main advantage of Clomiphene consists in its ability to restore spermatogenesis and production of testosterone by the testicles. That is why Clomiphene is actively used at the end of steroid cycle.
